I have found good information regar... RE: Chlorine dioxide + metabolic treatment. All these will be further discussed in the “Dose and Application” section below, but the point is that while the medical doctors authors of this article have my highest regards, in the future higher dose can be used to try increase Mebendazole effectiveness. These are the transporters used by cancer cells to push out chemotherapies in order to survive during chemo treatments. After six weeks of monotherapy, radiological evaluation showed near complete remission of metastatic lesions in the lungs and lymph nodes and a good partial remission in the liver. My email is [email protected]. Here is a PDF version available. * Radiotherapy (30*2 gy)+ TMZ (75mg/day) I’ll be sharing it to them. Besides all the studies in the lab indicating the effectiveness of Mebendazole against various cancer types, below are two published scientific case reports that are clear and coming from trust-able sources. When I find the time, I will get in contact with them. … Search results for at Sigma-Aldrich. 2. Hi Daniel, I am not on mebendazole regularly (although I do sometimes have some.) Here is an example that consolidated such a perspective http://jeffreydachmd.com/2016/05/cancer-as-a-parasitic-disease/ I think, successful researchers have to always keep their mind open, ready to consider new perspectives proposed by others and even better connect the available “dots” to generate new perspectives. His disease subsequently progressed after 24 months of mebendazole monotherapy. https://www.ncbi.nlm.nih.gov/pubmed/?term=29723506. Otherwise some drug companies could patent anti-cancer combos that have been proven to work, and then ask for money, from people or clinics using the combos. Answer to the question: 3BP, Thank you very much Daniel.I have to work on PP too much. ). Liver enzymes normalised and a subsequent round of CT scans confirmed the initial disease response. This seems to be the long-term treatment of cystic echinococcosis. Would be great to know a protocol or similar to avoid side effects. Actually I think Auranofin may help a lot if the patient has a functional tumor leading to high levels of DHEA – the combo of two will strongly affect the cancer cells and make them more susceptible to radio and chemo. The figure from the article shows clear hyperglycemia with a quadratically increasing fasting glucose level 3 years before typical diagnosis. Combining CiberKnife with strategies to enhance the activity of the immune system and/or metabolic strategies and/or pH strategy (https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/) and/or reducing intracellular antioxidant production (e.g. His doctor tried the MBZ approach in five other patients, with only one minor response as result. By browsing photobooths.co.uk you consent to our use of cookies. A patient with refractory metastatic colon cancer was treated with MBZ at the standard anthelmintic dose of 100 mg twice daily. can someone tell me mum has pancreatic and liver cancer i see this helps pancreatic but no mention of liver cancer and am wondering is it safe to use with liver cancer? Because if you have a bowl problem,you can’t do any treatments nor eating. Combination of Manumycin A and Mebendazole in Human Breast Cancer Cell Lines, a PhD thesis from 2010 https://uh-ir.tdl.org/uh-ir/bitstream/handle/10657/166/HADDADIN-.pdf?sequence=2, An article on Mebendazole, on a nice website of a breast cancer patient: https://magiccocktailquest.wordpress.com/2015/06/08/mebendazole/, Mebendazole is unique among tubulin-active drugs in activating the MEKâERK pathway https://www.nature.com/articles/s41598-020-68986-0. Hi Nissim, Mebendazole 100 mg tablet Lejal Laboratories, Inc. 2.01 100 mg/5 mL suspension, 30 mL Lejal Laboratories, Inc. 23.55 3.3.2 ANTIPROTOZOALS 3.3.2.1 AMEBECIDES Diloxanide 500 mg tablet (as furoate) Boots Company Furamide 8.08 125 mg/5 mL syrup, 60 mL (as furoate) Boots Company Furamide 83.00 Metronidazole 250 mg tablet G.D. Searle Anerobia 11.26 That reverted to normal after the drug was stopped. I was taking cimetidine but I stopped after somebody told me it was an oestrogen driver. Yes sir, I have read the article. Hello Alex I think I you would be interested in my story about mebendazole and cimitidine tablets curing me of cancer .I got the information about them from the same you have mentioned http://www.abovetopsecret.com I wrote about it about it on the same site and I also filmed the doctor when I explained to him about the drugs after he told me my cancer has gone .. Sorry here are some references about dandelion root. Its funny – i keep seeing this plant where i live, it seems to me very invasive. Janssen Pharma product descriptions states the following regarding the dose: “In controlled safety studies, humans have received from 100 to 1200 mg of mebendazole daily for up to 14 days with no reported side effects.” (Ref.). I see no reason why they would cancel the benefit of each other. It is very difficult for me to understand why this has not been applied to the clinic already. I like all of them. Wow. Fortunately, it seems that in the US there is still available a powder form that is cheap. According to recent research, Mebendazole may inhibit Multi Drug Resistence (MDR) transporters (Ref.). May you have all the good health in the world to help you achieve your goals in life. ..and when talking about Albendazole and liver support. It is easy for us to make misleading connections. Indeed many of the claims were cancelled. Hi Johan, This does not means that mebendazole will not work for other cancers, however, a formulation to increase its absorption is likely critical. Three additional colon cancer cell lines and three cell models with non-malignant phenotypes were subsequently tested, confirming selective colon cancer activity of MBZ. MBZ seemingly has repositioning potential for colorectal cancer therapy. This is greatly appreciated and will help others in having a reference point on the safety and tolerability of Mebendazole in humans at high dose. https://clinicaltrials.gov/ct2/show/NCT03628079 Intelligent wireless identification and tracking solutions are tomorrowâs enablers of your competitive edge. The primary anti cancer mechanism is related to the depolymerization of tubulin in human tumor cells caused by Mebendazole, inhibiting mitotic spindle formation, and therefore inducing mitotic arrest and apoptosis. I´do also have Omeprazol 2 times per day. The results were extremely promising: Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinoma https://www.ncbi.nlm.nih.gov/pubmed/21454232 The major problem is that unlike in mouse the mebendazole concentration in the blood could be really high, in human, the mebendazole concentration is only about 1 to 10% that in mouse. His blood work was not significantly changed during the two months. “A case of metastatic colon cancer treated with MBZ was described by Peter Nygren and Rolf Larsson in 2013 [24]. Because MBZ can be safely administered to adults and children at high doses over extended time periods, we propose that MBZ could be rapidly repurposed and clinically tested as a prospective therapeutic agent for many tumors that are dependent on Hh signaling. Substantial preclinical studies, as well as limited clinical trials, suggest noteworthy anticancer potency of these pleiotropic benzimidazoles, particularly as potent microtubule disrupting, anti-angiogenic, and anti-metastatic agents, inhibitors of the immune checkpoint, hypoxia-inducible factor, epithelial-mesenchymal transition, cancer stemness, and multidrug resistance protein 1, and inducers of apoptosis and M1 polarization. Fasting levels measured in 22 patients receiving 16 to 48 mg/kg/day ranged from undetectable to 300 ng/mL.6 Only 19% of the levels exceeded 75 ng/mL, and levels did not correlate with dosages.6 Our first patient’s random and fasting levels were 147 to 239 ng/mL. And since Cimetidine may very much increase the plasma level of Mebendazole (some say by 50%), in case we use that I would make sure the target dose is lower than what was used at John Hopkins Hospital. – it is well known that tumors have an exponential growth – so it is possible that nothing of what you did actually seriously affected the normal trend of the tumor growth The other supplements sound good. This demonstrated the need to do our best to increase the blood levels of Mebendazole by increasing its absorption (taking it with fats) and lowering its metabolism (with Cimetidine/Tgamet). Many thanks for your ongoing important help for the patients and their families! (It is working synergetic with Phlorizin) How can I work out if it is all the drugs that are making me feel bad? You found very important informations. “…There have been reports of reversible liver function disturbances, hepatitis, and neutropenia described in patients who were treated with mebendazole at standard dosages for indicated conditions. Others really wanted to buy males who overstrutted like peac*cks so they could put them in their place. Uma técnica usada aqui no Brasil principalmente para CA leucemia e usado junto com ascaridil. Itâs goal is to deliver value to the world in two major ways: Below is an image that consolidates the value MCS Formulas delivers through its products and actions, which comes with TRUST and FAIRNESS. Sembra che il proprietario di questo sito web abbia dimenticato qualcosa... se sei proprio tu e vuoi saperne di più puoi ottenere ulteriori informazioni aprendo una richiesta di assistenza Netsons I haven’t found yet the results reported. He did not experience any clinically significant adverse effects, and his quality of life was satisfactory. Thanks for the heads up on that. The effect of MBZ on MEK/ERK phosphorylation was inhibited by RAF/MEK/ERK inhibitors in THP-1 models, CD3/IL2 stimulated PBMCs and a MAPK reporter HEK-293 cell line. Great! https://www.cancertutor.com/dandelionroot/, “The diuretic effects of dandelion can lead to increased excretion of certain medications. Waiting until frank pancreatic cancer symptoms develops until a diagnosis is made can hardly be regarded as ethically acceptable. Dropping to all fours and groveling at the feet of the auctioneer tended to stimulate bidding. Curated gene signatures for a panel of TBAs in the LINCS Connectivity Map (CMap) database showed a unique strong negative correlation of MBZ with MEK/ERK inhibitors indicating ERK activation also in non-haematological cell lines. and if any, what was the response to that? We also ask that you complete our questionnaire so our pharmacy team can check that this product is suitable for you to buy. We did used Mebendazole and Doxi and we felt it helped a lot and had their own contribution to the extra years we’ve gained. To find out more read our privacy policy. Analysis of the diagnosis-specific activity of MBZ showed activity in 80 % of the colon cancer cell lines in the NCI 60 panel. Alternatively, with further imaging etc. Note: other anthelmintic drugs have also been shown to present strong anti cancer effects, but their main anti cancer mechanisms may be different. There are rare reports of reversible alopecia, urticaria, rash, gastro-intestinal upset, leukopenia, and neutropenia in some patients treated with high-dose MBZ (Ref.). My comments: as discussed in the article, the patient received only 200mg Mebendazole each day. Please keep us up to date with the results, since this info will help many other people. Any thoughts on these? (Ref.) Mebendazole, a well-known anti-helminthic drug in wide clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies across a number of different cancer types. Indeed, Mebendazole, alone or combined with chemo, has been shown to be effective against multiple forms of cancer cells, such as: A study, showed a high level of activity against leukaemia, colon cancer, CNS and melanoma cell lines, with lesser activity in breast, ovarian, renal and NSCLC lines (Ref.). You are very welcome. A little similar discussion we had here https://www.cancertreatmentsresearch.com/community/forum-to-discuss-treatment-protocols-and-drugsupplement-cocktail/reducing-supplement-protocol-berberine-metatrol-alamax/#post-828 It is in my top 3 drug list.I have seen good responces after taking mebendazole. Confidex delivers short-range wireless identification products and solutions for business-critical processes, such as access control, asset tracking, smart logistics, and smart ticketing. I would like to keep it as simple as possible with only those items that will actually work together. As far as the Norwegian CRC patient with great initial response…in the end brain mets turned up. as for my speed, i can be much faster when i am focused, much, much faster.https://www.youtube.com/watch?v=12u1nA7bXzc @daniel I guess very few would go on Mebendazole alone in a conventional setting. But I would not completely rely on that as single treatment strategy – instead, I would make sure I use other treatments in parallel. How can, we, the society accept something like this??? Also, you must treat internally with Ivermectin, can use the Pour on formula on Amazon, take amount per body weight, along with Valbazen also from Amazon taken per body weight. Sebagai salah satu Perguruan Tinggi Negeri, Universitas Negeri Medan (Unimed) juga ikut menyelenggarakn ⦠Those strong points are: The first website where I came across Mebendazole discussion was, I think, this one: http://www.abovetopsecret.com/forum/thread822776/pg1 I was happy to see in 2014, just a few months latter after I studied Mebendazole intensively and became convinced about its anti cancer relevance, a paper has come out from one of my favorite Anti Cancer Foundation, i.e. © Cancer Treatments - from Research to Application 2021, Trust & Expertise and we Donate 50% for Cancer PatientsÂ, Mebendazole: A Cancer Fighting Drug We Find at the Supermarket. In addition, Mebendazole is known to be poorly absorbed in the body and there are ways to increase its absorption. One would try Essential Forte as it´s widely used in bodybuilders comunity when/after they stop with steroid course to quickly detox they liver so they can start with the next steroid course as soon as possible. Here is that nice paper published in 2014: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/ By that time, we were already using it. Myelosuppression was the main dose limiting toxicity. Thanks to you and this blog, I was able to connect with shaneclark as well. Based in Exton, PA, Touchstone Home Products has been part of this community since 2005. Jeff, do you know how the Hopkins doctors got their supply of the 500 mg mebendazole tablets? I know doctors who are even suggesting to their patients not to use it …. Life style (including diet and exercise) would be the base to address inflammation, and next to that we can add drugs such as Low Dose Aspirin (100mg/day) and supplements such as Omega 3 and Curcumin. jamieson, windsor on, canada - form 3500a, 3500b 7/1/17 to 9/30/17 2017-8873 stute, hank paragon vision sciences, mesa, az - eir 2016 2017-8874 2017-8875 remedy pharmaceuticals His high grade brain tumor progressed again before he was enrolled in the trial. The trial is a phase 1 trial, the goal is to test the safety and highest tolerable dose of mebendazole for kids. With regard to speed i write to you. Search by Keyword (leave blank to view all jobs) Share these Jobs. A number of possible combinations with other drugs are discussed in the Appendix. Congratulations to my chairman Dr Vaughn Starnes 100th AATSâ¦â It was found out earlier this month. ). The drug is among those on the World Health Organizationâs list (WHO) (Ref.). Both the Kruidvat drug store chain as its twin compagny Trekpleister sell them at 2.59 euro (2.75 USD today) OTC in the Netherlands (I am Dutch). Report suggests anti-cancer effects in pancreatic, colorectal and other cancers. While he was on CCNU and Tamoxifen he also took 15mg of Melatonin. Therefore, to address the challenge related to reaching a high level of mebendazole plasma level, which on one hand is due to the bad absorption and on the other hand due to a strong first pass metabolism in the liver, the following actions can be taken: The low bioavailability is also probably why its side effects are very limited. Mebendazole is rapidly metabolized to less toxic metabolites by the liver, and this could be another reason for its low toxicity (Ref. Also, if you are aware of any other treatments with potential, we here are always glad to know them and research them. deliver some of the best product combination of Purity, Strength and Fair Price (as well as Compiled Packages). Atom, I really like this one for pancreatic diagnosis. High Strength This was further supported when gene expression signatures were compared in the CMAP database; ABZ ranked very low when MBZ was used as the query signature. Specifically, every person is different and there will be always some cases of people having undesired reactions to some drugs even if they are safe for most of the people. Analysis of chemical similarity of the hit compounds revealed several distinct clusters, among them the antiparasitic benzimidazole group. Thank you for pointing out Essential Forte. @daniel Select to view the full details of the job. Regarding your observation, i.e. So what I would do is to introduce it between a cyle of chemo at a low dose (i.e. ovarian cancer (Ref.). Based on the above, a person of 50kg could use up to 2.5g Mebendazole for months to years. These events, along with glomerulonephritis and agranulocytosis, have also been reported with dosages substantially above those recommended and with treatment for prolonged periods of time…”. Btw, have you seen the discussion with Manuel on this forum. Significantly, there are also two case reports of anti-cancer activity in humans. However, the patient experienced elevated liver enzymes (AST and ALT), so MBZ was temporarily stopped and then started at half the dose, with the patient reporting no ill effects. Such doses are indeed in the plasma level reported to achieve anti cancer effects in the lab. The data are summarised and discussed in relation to suggested mechanisms of action. 4 out of 24 assessable patients (16%) had a tumor marker response with a fall of at least 50% from baseline values and another patient had a prolonged period of stable marker response. how are you? This one impressed me. In the two successful case reports referenced above, the patients have used the minimum dose typically used against worms, i.e. Albendazole has been indicated to be effective against, e.g. Did you used this combination Mebendazole+Doxicicline? In conclusion, there is no way in my mind to connect HCA with tumor growth. Carl, Thank you, Carl! I emailed Dr. Pan Pantziarka, one of the authors of Repurposing Drugs in Oncology (ReDO)âmebendazole as an anti-cancer agent and the Programme Director Drug Repurposing at anticancerfund.org, he mentioned that they might be able to help in assessing the case and maybe give advise to the oncologist based on their findings. This lasted for two months. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. In the present study we investigated whether MBZ induced ERK activation is shared by other tubulin binding agents (TBAs) and if it is observable also in other human cell types. Remark – as in the clinical trials, in the next remaining 3 cycles TMZ might be updated up to 200 mg/day based on the blood counts results. Increased Absorption. never heard about dandelion root being potent. first, thank you for all the work you are doing! A decline in plasma vascular endothelial growth factor levels was observed. * Tumor resection (quite good with no damages) Here is the product description https://www.janssen.com/canada/sites/www_janssen_com_canada/files/product/pdf/ver11192014cpm.pdf, At high dose, it has been found to possibly induce bone marrow suppression in patients chronic liver disease (Ref.) Mebendazole became and remained one of my preferred drugs since I learned about it at the beginning of 2014. One month on, one month off It depends what you mean by working. But that is powder version. Here is an example of a version that is available over the counter at a super market in the Netherlands: https://www.kruidvat.nl/kruidvat-anti-worm-mebendazol-100mg-tabletten/p/1023933 . Here are two clinical trials on Mebendazole: Although a dose of 50 mg/kg/day seems very high, here is a man reporting that his son takes a very high dose of mebendazole as a part of a clinical trial, using 4.5g/day without significant side effects (Ref.). Care Oncology Clinic in London, UK: http://careoncologyclinic.com/ They usually seem to give to their patients a combination of drugs including Sratin + Metformin + Doxycycline + Mebendazole. Ergin, Thanks. Indeed, that is why we use it in cycles to prevent them. My question is related to my brother, 45 years old, with GBM grade IV (right temporal, since 3/2019). https://patents.google.com/patent/US20190175560A1/en Hectoria, Is there any problem to take simultaneously(without rotating as COC suggest) mebendazole/febendazole without cancelling any benefits from taking them? 3. early warning before symptoms even emerge. You may also want to read the posts here https://www.cancertreatmentsresearch.com/community/pancreatic-cancer/. When you have more info on Cyberknife locations that are willing to treat ACC, please share that on the ACC page too so that other can make use of that info https://www.cancertreatmentsresearch.com/acc-adrenocortical/ Thank you. In my view Mebendazole is a safe drug. Then buy Martyâs permetherin and mix with either body lotion 50/50 mix or a coconut oil spray to spray body and scalp after bathing. Unsurprisingly, alternative clinics that can combine various alternative approaches have reported very impressive results. I am not aware of any major safety issues related to Mebendazole used by patients with liver metastasis. daniel, And to me it seems that mebendazole does not have as brutal side effects as chloroquine for instance ( retinopathy, nerve damage etc). The results of this study suggest that the recommended dose for further study is 1,200 mg twice daily for 14 days in a 21-day cycle. Alex, Thank you Alex! Origin of drug and radio-refractory clones, cancer stem-like cells, and rapid angiogenesis and metastasis are among the primary concerns that limit the efficacy of anticancer treatments, emphasizing the urgency of developing new therapeutics. Following the above discussions, I would take the daily dose split into two, during or just after breakfast and dinner, if possible together with Cimetidine 400mg 2x/day. You could start your research by using this keywords in Google search “hydroxycitrate cancer growth”. Thank you. Here is an article explaining in details the price, activity and vision of this clinic http://www.telegraph.co.uk/wellbeing/health-advice/crowdfunding-cure-cancer/, Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinoma https://www.ncbi.nlm.nih.gov/pubmed/21454232, Repurposing Drugs in Oncology (ReDO)âmebendazole as an anti-cancer agent https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/. There is an evolving technology base that perhaps could be applied to a very wide range of treatments. Repurposing the antihelmintic mebendazole as a hedgehog inhibitor https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297232/. Ergin. Thank you Vincent. Many thanks and we’ll investigate it further! MBZ is contraindicated during pregnancy, due to its potential anti-angiogenesis properties. As we will discuss further, the only drawback with Mebendazole is that due to its absorption which can be different in different patients, the results may vary from patient to patient. Clinical trials can waste decades and decades attempting monotherapy treatments that will never be effective. Many thanks for this enriching information, it sure help and encourage us! This is an aggressive cancer so the patient and doctors will need to move fast in terms of considering options and starting their application. Thus, HCA question could be addressed in the anti cholesterol strategy post or the post on ACLY inhibition. As an antiparasitic, MBZ avidly binds nematode tubulin and causes inhibition of intestinal microtubule synthesis. Daniel, Here we'll guide you to the very best prices available today. They might want to confirm this with a dose of 3-BP. We found your conversation with @Da... metabolic treatment ALA to inhibit fermentation while on chemo ? Will certainly try it in my practice. Or is there any protocol / substance which is not recommened to take during the Mebendazole treatment? That is really a huge dose. And it comes with good anti cancer effects. Therefore, using Mebendazole during chemo treatments may lead to increase effectiveness of the conventional therapies. Factors like high attrition rates, huge investments, patients’ heterogeneity, and diverse molecular subtypes have challenged the rapid development of anticancer drugs. Setelah SKD maka tahapan selanjutnya dari seleksi CPNS adalah pelaksanaan Seleksi Kompetensi Bidang (SKB). Background: First, I will start this post by wishing all the readers a Happy New Year full of health for you and your family, and a lot of success in everything you do! Between 18-feb and 6-march we only used aspirin and cbd oil A further five patients have been treated, with one experiencing a minor remission [Private communication from Peter Nygren].” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/. Those tablets come in 100mg or 500mg version. Based on all the research available, I would expected the highest chance of effectiveness of Mebendazole, against, However, given the low cost, limited to now side effects, its availability and potential, I would still try it for the other cancer types (next to other treatments), specifically for the aggressive cancer types. In a clinical trial, Albendazole was given orally on a day 1â14 of a 3 weekly cycle, starting at 400 mg BD with dose escalation until 1,200 mg BD. This is a mechanism similar to that one I already described in details in the post on Griseofulvin: https://www.cancertreatmentsresearch.com/decide/ so I will not discuss again, here, the details of the mechanism. The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents. My wife (breast er+,pr-,her2-, met liver,bone... Dear @zuchzeus , Such a strong result for a single agent treatment is encouraging. That is ofcourse a general statement. I find it interesting as a concept and since there are no special side effects I would try it.
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